Triclabendazole is an Antihelminthic agent against Fasciola species. The mechanism of action against Fasciola species is
not fully understood at this time. In vitro studies and animal studies suggest that triclabendazole and its active
metabolites (sulfoxide and sulfone) are absorbed by the outer body covering of the immature and mature worms, causing a
reduction in the resting membrane potential, the inhibition of tubulin function as well as protein and enzyme synthesis
necessary for survival. These metabolic disturbances lead to an inhibition of motility, disruption of the worm outer
surface, in addition to the inhibition of spermatogenesis and egg/embryonic cells.