By promoting the release of acetylcholine, inhibiting cholinesterase, and stimulating ganglionic neurons, Pyrantel
serves as a depolarizing neuromuscular blocking agent in helminths. This causes extensive depolarization of the helminth
muscle membrane, resulting in tension to the helminth's muscles, leading to paralysis and release of their attachment to
the host organism intestinal walls.
This action is unlike piperazine, which is a hyperpolarizing neuromuscular blocking agent that causes relaxation of the
helminth muscles, leading to a subsequent detachment from the intestinal wall. Excretion of the parasites in the feces
occurs by normal peristalsis.