PRODUCTS

GRANISETRON HYDROCHLORIDE API (Human)


GRANISETRON HYDROCHLORIDE

Product Description:

  • Therapeutic Category : Serotonin 5HT3 receptor antagonist; treatment of nausea and vomiting.
  • CAS Number : 107007-99-8
  • Molecular Formula : C18H25ClN4O
  • Molecular Weight : 348.9
  • Mesh Size : As per customer requirement
  • Appearance : White or almost white powder.

Mechanism of Action:

Granisetron is a potent, selective antagonist of 5-HT3 receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Uses:

Granisetron is used for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).