The primary mechanism of action for Citicoline is as a source of Choline. Choline is a nutrient similar to the B Vitamins that are necessary for the brain to be able to make the acetylcholine neurotransmitter. However, the vast majority of the population does not get the recommended amount of choline from their diet which can lead to mental impairment even with minor deficiencies.

Citicoline can help to supplement the amount of choline in your bloodstream which promotes greater acetylcholine production. What is most interested about Citicoline is that it has proven more effective at increasing brainpower than taking equivalent amounts of choline supplements. This is because Citicoline is actually more bioavailable and a closer precursor to acetylcholine. After taking a Citicoline dosage, this compound is absorbed into the bloodstream fairly quickly and then crosses the blood-brain barrier, reaching the brain.

The two main components of the supplement, cytidine, and choline, are broken down and then widely distributed. As it becomes incorporated into phospholipids it helps to activate their continued biosynthesis. A number of different neurotransmitters and brain chemicals are also affected by Citicoline. It acts as a precursor to Acetylcholine and helps to influence a number of cognitive processes through this action. Dopamine and Norepinephrine levels are also increased throughout the central nervous system. This may also be why many users report their overall stress levels decrease and a feeling of general well-being to be improved while using this supplement. Citicoline may also help to protect the brain. This includes the possible activation of a number of anti-oxidants. This helps to rid the brain of a number of poisons and toxins, improving overall health. The increase in phospholipid metabolism is also thought to help aid in this brain protection effect, keep the individual cell membranes better able to communicate with one another

Citicoline used for the treatment, supportive care, and diagnostic of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.