Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy
production, ultimately leading to immobilization and death of the parasite. It works by binding to the
colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. As cytoplasmic
microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the
glycogen stores of the parasites are depleted. Degenerative changes in the endoplasmic reticulum, the mitochondria of
the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate
(ATP), which is the energy required for the survival of the helminth.